Funded by U.S. company Cannabics Pharmaceuticals, a firm focused on the development of cannabinoid therapies for cancer treatment, Israeli researchers have demonstrated the anti-tumor efficacy of CBG and CBC against human gastrointestinal cancer cell lines.
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January 27, 2020
Posted by Andrea Sparr-Jaswa
International Medical Cannabis News
TEL AVIV, Israel and BETHESDA, Maryland, Jan. 27, 2020 /PRNewswire/PRESS RELEASE -- Cannabics Pharmaceuticals Inc. (OTCQB: CNBX), a leader in personalized cannabinoid medicine focused on cancer and its side effects, announced today that in a series of tests conducted at the company's High Through-put Screening (HTS) facility in Israel, it has been shown that the cannabinoids CBC (cannabichromene) and CBG (cannabigerol) both exhibit anti-tumor properties, tested on human gastrointestinal cancer cells.
CBC is an additional non-intoxicating cannabinoid and is one of the naturally occurring phytocannabinoids. It bears a host of potential positive therapeutic qualities and may promote antimicrobial, anti‐inflammatory, analgesic, and neurogenesis activity. It is particularly found in younger cannabis plants, albeit in small quantities.
In these tests, the HTS platform was utilized to screen the necrotic effects of a variety of cannabinoids on human gastrointestinal cancer cells, in addition to other cancer types previously tested. CBC and CBG were both shown to induce significantly higher rates of necrosis in these cancer cells compared to other cannabinoids, thus strengthening previously obtained results. © credit | Cannabics Pharmaceuticals
Cannabinoid extract causing necrosis in gastrointestinal cancer cell line. The Yellow color is a marker for necrosis. On the right - control, on the left – after treatment with cannabinoids
Dr. Yaakov Waksman, the company's head of cannabinoid research, said, "My working assumption is that these results show that a correlation may exist between a cannabinoid's Topological Polar Surface Area (TPSA) value and its ability to induce anti-tumor activity, diminishing cancer cell's viability rates. CBC and CBG, as neutral cannabinoids, were both found to have a TPSA value which allows t
